Influence of radiation source geometry on determination of (111)In and (90)Y activity of radiopharmaceuticals.
Identifieur interne : 001E08 ( Main/Exploration ); précédent : 001E07; suivant : 001E09Influence of radiation source geometry on determination of (111)In and (90)Y activity of radiopharmaceuticals.
Auteurs : RBID : pubmed:19623093Descripteurs français
- Wicri :
- geographic : Slovénie.
English descriptors
- KwdEn :
- MESH :
- chemical , analysis : Indium Radioisotopes, Yttrium Radioisotopes.
- geographic : Slovenia.
- methods : Radiometry, Specimen Handling.
- standards : Radiometry, Specimen Handling.
- Radiation Dosage, Reproducibility of Results, Sensitivity and Specificity.
Abstract
Yttrium-90 (Y)-labelled peptides such as DOTATOC and antibodies such as Zevalin are widely used in radionuclide therapy. Indium-111 (In) is used as a Y surrogate for imaging and dosimetry purposes. We aimed to investigate accuracy, geometry (vials and syringes) and volume dependencies for both radionuclides in several different radionuclide calibrators.
DOI: 10.1097/MNM.0b013e32832fd0ea
PubMed: 19623093
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Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of radiation source geometry on determination of (111)In and (90)Y activity of radiopharmaceuticals.</title><author><name sortKey="Peitl, Petra Kolenc" uniqKey="Peitl P">Petra Kolenc Peitl</name><affiliation wicri:level="1"><nlm:affiliation>Department for Nuclear Medicine, University Medical Centre Ljubljana, Zaloska bUniversity of Ljubljana, Faculty of Pharmacy, Askerceva, 1000 Ljubljana, Slovenia. petra.peitl@kclj.si</nlm:affiliation><country xml:lang="fr">Slovénie</country><wicri:regionArea>Department for Nuclear Medicine, University Medical Centre Ljubljana, Zaloska bUniversity of Ljubljana, Faculty of Pharmacy, Askerceva, 1000 Ljubljana</wicri:regionArea></affiliation></author><author><name sortKey="Tomse, Petra" uniqKey="Tomse P">Petra Tomse</name></author><author><name sortKey="Kroselj, Marko" uniqKey="Kroselj M">Marko Kroselj</name></author><author><name sortKey="Socan, Aljaz" uniqKey="Socan A">Aljaz Socan</name></author><author><name sortKey="Hojker, Sergej" uniqKey="Hojker S">Sergej Hojker</name></author><author><name sortKey="Pecar, Slavko" uniqKey="Pecar S">Slavko Pecar</name></author><author><name sortKey="Stopar, Tanja Gmeiner" uniqKey="Stopar T">Tanja Gmeiner Stopar</name></author></titleStmt><publicationStmt><date when="2009">2009</date><idno type="doi">10.1097/MNM.0b013e32832fd0ea</idno><idno type="RBID">pubmed:19623093</idno><idno type="pmid">19623093</idno><idno type="wicri:Area/Main/Corpus">001D67</idno><idno type="wicri:Area/Main/Curation">001D67</idno><idno type="wicri:Area/Main/Exploration">001E08</idno></publicationStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Indium Radioisotopes (analysis)</term><term>Radiation Dosage</term><term>Radiometry (methods)</term><term>Radiometry (standards)</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Slovenia</term><term>Specimen Handling (methods)</term><term>Specimen Handling (standards)</term><term>Yttrium Radioisotopes (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Indium Radioisotopes</term><term>Yttrium Radioisotopes</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Slovenia</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Radiometry</term><term>Specimen Handling</term></keywords><keywords scheme="MESH" qualifier="standards" xml:lang="en"><term>Radiometry</term><term>Specimen Handling</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Radiation Dosage</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Slovénie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Yttrium-90 (Y)-labelled peptides such as DOTATOC and antibodies such as Zevalin are widely used in radionuclide therapy. Indium-111 (In) is used as a Y surrogate for imaging and dosimetry purposes. We aimed to investigate accuracy, geometry (vials and syringes) and volume dependencies for both radionuclides in several different radionuclide calibrators.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">19623093</PMID><DateCreated><Year>2009</Year><Month>09</Month><Day>02</Day></DateCreated><DateCompleted><Year>2009</Year><Month>11</Month><Day>12</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1473-5628</ISSN><JournalIssue CitedMedium="Internet"><Volume>30</Volume><Issue>10</Issue><PubDate><Year>2009</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Nuclear medicine communications</Title><ISOAbbreviation>Nucl Med Commun</ISOAbbreviation></Journal><ArticleTitle>Influence of radiation source geometry on determination of (111)In and (90)Y activity of radiopharmaceuticals.</ArticleTitle><Pagination><MedlinePgn>807-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1097/MNM.0b013e32832fd0ea</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Yttrium-90 (Y)-labelled peptides such as DOTATOC and antibodies such as Zevalin are widely used in radionuclide therapy. Indium-111 (In) is used as a Y surrogate for imaging and dosimetry purposes. We aimed to investigate accuracy, geometry (vials and syringes) and volume dependencies for both radionuclides in several different radionuclide calibrators.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">YCl3 and InCl3 solutions were gravimetrically dispensed into the most frequently used containers. In each container several dilutions of the parent solutions were performed. Mass, activity and time were recorded for each calibrator and measurement. Aliquots of both parent solutions were calibrated at the National Metrology Laboratory, Vienna, Austria (BEV). From our measurements and results from BEV, correction factors were determined and further partitioned into calibration, geometry and volume correction factors.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Using the nominal calibration factors provided by the manufacturer, measured activity in P6 vials was overestimated by up to 25% for In, depending on the calibrator. Y activity was either underestimated (by up to 20%) or overestimated (by up to 25%) using different radionuclide calibrators. This is the result of the difference in containers used to set the manufacturer's calibration factor values and the containers used in nuclear medicine departments and in this study. There was little geometry dependence for glass vials but strong geometry dependence for syringes for both radionuclides in all calibrators.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The results should constitute a warning for all personnel responsible for preparation of radiopharmaceuticals. Every nuclear medicine department should incorporate a proper quality-control regimen for radionuclide calibrators and a quality-assurance system.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Peitl</LastName><ForeName>Petra Kolenc</ForeName><Initials>PK</Initials><Affiliation>Department for Nuclear Medicine, University Medical Centre Ljubljana, Zaloska bUniversity of Ljubljana, Faculty of Pharmacy, Askerceva, 1000 Ljubljana, Slovenia. petra.peitl@kclj.si</Affiliation></Author><Author ValidYN="Y"><LastName>Tomse</LastName><ForeName>Petra</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Kroselj</LastName><ForeName>Marko</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Socan</LastName><ForeName>Aljaz</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Hojker</LastName><ForeName>Sergej</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Pecar</LastName><ForeName>Slavko</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Stopar</LastName><ForeName>Tanja Gmeiner</ForeName><Initials>TG</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Comparative Study</PublicationType><PublicationType>Evaluation Studies</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nucl Med Commun</MedlineTA><NlmUniqueID>8201017</NlmUniqueID><ISSNLinking>0143-3636</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Yttrium Radioisotopes</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiation Dosage</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Radiometry</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName><QualifierName MajorTopicYN="Y">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Sensitivity and Specificity</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic">Slovenia</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Specimen Handling</DescriptorName><QualifierName MajorTopicYN="Y">methods</QualifierName><QualifierName MajorTopicYN="Y">standards</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Yttrium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2009</Year><Month>7</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2009</Year><Month>7</Month><Day>23</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2009</Year><Month>11</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1097/MNM.0b013e32832fd0ea</ArticleId><ArticleId IdType="pubmed">19623093</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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